These functions estimate the optimal (maximal or minimal) sensitivity of a PRS.
Usage
opt_se(
k,
pve,
sp,
n.bins = 1000,
thresh.vector = seq(from = 1, to = n.bins, by = 10),
direction = "max"
)Arguments
- k
(numeric; range 0-1) Population prevalence of the disease of interest
- pve
(numeric; range 0-1) Proportion of variability explained by the PRS
- sp
(numeric; range 0-1) Specificity
- n.bins
(integer) Number of bins for estimating the AUC (default = 100)
- thresh.vector
(numeric) Vector of thresholds
- direction
(character)
"max"or"min"